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Additional Information

                                    ARUP BHATTACHARYA - CURRICULUM VITAE.

Disclaimer – No claims of any nature is made and reader should be aware that homeopathy is not a medically regulated profession in Ontario as yet and no claims directly or by association is made what so ever from past and current education, training and experiences 

EDUCATION AND PROFESSIONAL TRAINING    

1. August 1999 – June 2005.

PhD from Roswell Park Graduate Division of SUNY, Buffalo, in Molecular and Cellular Biophysics program under Department of Cancer Biology with interaction with Dept of Pharmacology & Therapeutics. Awarded full scholarship and fellowship by Roswell Park Cancer Institute. Title of thesis: NON-INVASIVE IN VIVO ASSESSMENT OF TUMOR HYPOXIA USING FUNCTIONAL MAGNETIC RESONANCE (fMR) IMAGING DURING THERAPY IN HUMAN HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) XENOGRAFTS: IMPLICATIONS FOR ASSESSING THERAPEUTIC EFFICACY. Research project involved use of spin echo based functional magnetic resonance (fMR) imaging for non-invasive detection of hypoxia and its impact on intratumoral drug distribution in nude mice bearing human head and neck squamous cell carcinoma A253 (well-differentiated, less sensitive) & FaDu (uniformly poorly differentiated, sensitive).

2. October 2002.

Completion of three years study in classical homeopathy with scholarship from the International Academy of Classical Homeopathy, New York. This is a homeopathy course under George Vithoulkas - the winner of 1996 Right Livelihood award (alternate noble prize) for his contribution to the revival of classical homeopathy.

3. December 1997

Masters in Psychology (MA) from Annamalai University, India.

4. March 1997

Postgraduate diploma in Guidance and Counseling (PGDGC) from Annamalai University, India

5. Dec 1996

Diploma in Homeopathic Pharmacy (DHPh) from British Institute of Homeopathy, UK.

6. August 1994

Completion of Doctorate of Homeopathic Medicine (HMD) from British institute of Homeopathy, UK.

7. May 1994

Completion of Proficiency certificate in Acupuncture from Chinese Academy of Science.

8. March 1992

Diploma in Acupuncture from Open International University of Complementary Medicine, Sri Lanka.

9. October 1992

Diploma in homoepathy  (DIHom) from British Institute of Homeopathy, UK. 

10. 1985

MS in Biophysics from Cancer Research Institute under University of Bombay

11. 1983

BS in Microbiology from University of Bombay.

OTHER EDUCATION 

1. December 1988

Diploma in Management Studies (DMS) from University of Bombay, India. 

2. March 1993

Completion of Baccalaureate in law (LLB) from University of Bombay.

3. January 1991

Diploma in Export Import Management from Indian Merchants Chambers, Bombay, India. 

CAREER IN SCIENCE AND HOMEOPATHY 

1. September 19, 2005 onwards

Research affiliate at the Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY. Current project involves continuation of the thesis work that also includes study of tumor vessel maturation by selenium compounds.

2. September 2, 2004 till August 31 2004

Research Technologist in the Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY, USA. This was a research posting and the appointment has been given concurrent to my end stage of PhD completion when I was on optional practical training (OPT) stage of the student visa.

3. April 2002 onwards
1. Teaching homeopathic medicine at postgraduate level.
2. Since October 2004, adjunct faculty with Akamai University for homeopathic education.
3. Homeopath practitioner in North America.
   

4. July 1992 till august 1999

Director, coordinator – Centre for Homeopathic Cure, India. Responsibilities included overseeing activities of homeopathic medical doctors at the Centre, teaching intern homeopathic medical doctors, organizing seminars, homeopathic practice, managing finances coordinating different staff and functions. 

5. April 1996 till March 1997

Managing Editor - Health Newsletter, India.

6. 1995

Visiting Professor at the Open International University of Complementary Medicine, Sri Lanka teaching homeopathy.

CAREER - OTHERS 

1. July 1989 till August 1999

Director - Alpha Trade Links, India. Consultants to Himedia Laboratories P Ltd., Ceekay Daikin Ltd. and other corporations on international trade related matters. 

2. June1996 till March 1999

Faculty member – Institute of Management and Professional Studies, Mulund, Bombay, India. Taught International marketing to graduate students. 

3. January 1999 till March 1999

Visiting Faculty - Melange Institute of Management, India. Taught International marketing to graduate students.

4. May 1988 till July 1989

Manager - Exports & Imports. Intec Polymers Ltd., Bombay, India

5. May 1987 till May 1988

Purchase Executive, Intec Polymers Ltd., Bombay, India

6. June 1985 till September 1986

Project Executive, Thomas Baker Pvt. Ltd., Bombay, India.           

AWARDS

1.      American Institute for Cancer Research postdoctoral grant for 2 years effective July 1^st. 2006

2.      American Association for Cancer Research instituted AACR-AFLAC Scholar-in-Training Award for 2006;

3.      International Society for Magnetic Resonance in Medicine Award for annual meeting, 2006;

4.      Scholarship from Roswell Park Cancer Institute to attend 7^th. International Summer School of Biophysics, Croatia, 2000;

5.      Fellowship with scholarship at Roswell Park Cancer Institute & SUNY, Buffalo, NY for PhD studies;

OTHER AWARDS

1.      Doctorate of Science (DSc) - Honoris-Causa by Open International University of Complementary Medicine for services in homeopathy;

2.      Recipient of College Merit Scholarship twice at Baccalaureate level;

3.      Fellow of the International Laser therapy Association;

4.      Fellow of the British Institute of Homeopathy;

5.      Fellow member of United Writers’ Association, India;

6. Fellow of the Homeopathic Foundation, Sri Lanka;

7. Fellow of the Acupuncture Foundation of Sri Lanka;

8. HD (Homeopathic Doctor) by NUPATH, Canada. 

MEMBERSHIPS

1.      American Association for Cancer Research (AACR);

2.      International Society For Magnetic Resonance in Medicine (ISMRM);

3.      American Association of Physicists in Medicine (AAPM);

4.      Homeopathic Medical Council of Canada;

5.      National United Professional Association of Trained Homeopaths (NUPATH), Canada;

6.      Associate member of the Institute of Company Secretary of India;

7.      International German Homoeopathic Society;

8.      Commonwealth Institute of Acupuncture & Natural Medicine;

9.      Associate member of the Institute of Company Secretaries of India;

10. Member of the Acupuncture Foundation of SriLanka;

11. Ex-member of Bombay Management Association;

12. Ex-associate member of the International Federation of Practitioners of Natural Therapeutics, UK. 

PUBLICATIONS 

1. Bhattacharya A, Tóth K, Durrani FA, Cao S, Slocum HK, Chintala S, Rustum Y M. Hypoxia Specific Drug Tirapazamine Does Not Abrogate Hypoxic Tumor Cells in Combination Therapy with Irinotecan and Methylselenocysteine in Well-Differentiated Human Head and Neck Squamous Cell Carcinoma A253 Xenografts. In-press, Neoplasia.

2. Bhattacharya A, Seshadri M, Oven S D, Tóth K, Vaughan M, Rustum Y.M. Tumor vascular maturation and improved drug delivery by organoselenium compound methylselenocysteine. In-press, Clinical Cancer Research.

3. Cao S, Durrani FA, Bhattacharya A, Yu Y, Rustum YM. Enhanced irinotecan toxicity in UDPGT deficient rats: Role of UDPGT1A in irinotecan detoxification. Proc. Am. Institute for Cancer Res., 2008.

4. Bhattacharya A, Tóth K, Cao S, Azrak R. G, Durrani F A, Rustum Y M. 5-Methylselenocysteine (MSC) causes tumor vessel maturation leading to synergistic antitumor effect in human xenografts. Proc. Am. Institute for Cancer Res., 2007.

5. Seshadri M, Bhattacharya A, Tóth K, Rustum Y M. Contrast-enhanced MRI of the vascular response of human tumor xenografts to the chemopreventive agent selenium in vivo: Implications for combination therapy. Proc. Am. Assoc. Cancer Res., 2007.

6. Bhattacharya A, Tóth K, Cao S, Azrak R. G, Durrani F A, Rustum Y M. Se-(Methyl)selenocysteine causes tumor vessel maturation leading to synergistic antitumor effect in human xenografts. The Journal of Nutrition, 137(1S), 278S, 2007.

7. Seshadri M, Mazurchuk R, Spernyak J A, Bhattacharya A, Rustum Y M, Bellnier D A. Activity of the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) against human head and neck carcinoma xenografts. Neoplasia, 8(7), 534-542, 2006.

8. Bhattacharya A, Mazurchuk R, Spernyak J. A, Tóth K, Magnano, C.R, Cao S, Azrak R. G, Durrani F A, Rustum Y M. Tumor vessel maturation by 5-Methylselenocysteine (MSC) results in synergistic antitumor effect in human head and neck squamous cell carcinoma (HNSCC) xenografts. Proc. Am. Assoc. Cancer Res., 2006.

9. Bhattacharya A, Mazurchuk R, Spernyak J. A, Cao S, Durrani F A, Rustum Y M. Serial spin echo based BOLD fMR imaging can predict chemotherapy response in head and neck squamous cell carcinoma (HNSCC) xenografts. Proc. International Society of Magnetic Resonance in Medicine, 2006.

10. Seshadri M, Mazurchuk R, Spernyak J. A, Bhattacharya A, Rustum Y M, Bellnier, D.A. Tumor response of human head and neck squamous cell carcinoma (HNSCC) xenografts to the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Proc. Am. Assoc. Cancer Res., 2006.

11. Cao S, Bhattacharya A, Durrani F A, Fakih M. Irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer (Review Article). Expert opinion on pharmacotherapy, 7, 687-703, 2006.

12. Yin M-B, Li Z-R, Tóth K, Cao S, Durrani F A, Hapke G, Bhattacharya A, Azrak R G, Frank C, Rustum Y M. Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase and hypoxia-inducible factor 1a expression, resulting in reduced angiogenesis. Oncogene, 25, 2509-2519, 2006.

13. Bhattacharya A, Tóth K, Mazurchuk R, Spernyak J A, Slocum H K,  Pendyala L, Azrak R, Cao S, Durrani F A, Rustum Y M,: Lack of microvessels in well differentiated regions of head and neck squamous cell carcinoma (HNSCC) A253 is associated with fMR imaging detectable hypoxia, limited drug delivery and resistance to irinotecan therapy. Clinical Cancer Res, 10, 8005 – 8017, 2004.

14. Bhattacharya A, Tóth K, Azrak R, Pendyala L, Spernyak J, Cao S, Durrani F A, Mazurchuk R, Slocum H K, Rustum Y M. Resistance to irinotecan is associated with lack of microvessels, hypoxia and limited drug delivery in the well differentiated parts of human head and neck squamous cell carcinoma (HNSCC) A253. Proc. Am. Assoc. Cancer Res. 45, 2004.

15. Cao S, Durrani F A, Moser M T, Bhattacharya A, Foster B A, Rustum Y M. Se-(Methyl)Selenocysteine (MSC) potentiates the antitumor activity of Taxotere against Prostate Cancer inTramp model. Proc. Am. Assoc. Cancer Res, 45, 2004.

16. Bhattacharya A, Azrak R, Toth K, Cao S, Durrani F, Pendyala L, Mazurchuk R, Rustum Y M - Tumor hypoxia and differentiation status are markers associated with response to irinotecan (FU therapy) of xenografts bearing squamous cell carcinoma of the head and neck (SCCHN) tumors. Proc. Am. Assoc. Cancer Res. 44, 2003.

17. Bhattacharya A – The enigma of coffee restriction in homeopathic treatment. Asian Homeopathic Journal, 6(4), 33-36, 1996.

18. Bhattacharya A – Dietary effect on criminal behaviour.  Health Newsletter, 15, 4, 1996.

19. Bhattacharya A – A new model of health and diseases. Health Newsletter, 1996.

20. Bhattacharya A – Alleviating Anxiety neuroses nutritionally. Health Newsletter, 1996.

21. Bhattacharya A – Garlic – the health Panacea. Health Newsletter, 1996.

22. Bhattacharya A – Understanding minerals. Health Newsletter. 1996 & 1997.

SYMPOSIA – INVITED SPEAKER/REVIEWER

1. ISMRM – ESMRM 2007 joint annual meeting scientific abstract reviewer;
2. Reviewer for scientific journal such as Molecular Cancer Therapeutics, Clinical Cancer Research.